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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1972 1
1975 3
1976 5
1977 1
1978 3
1979 1
1980 5
1981 12
1982 3
1983 4
1984 5
1985 4
1986 5
1987 6
1988 5
1989 4
1990 13
1991 5
1992 11
1993 14
1994 15
1995 13
1996 17
1997 20
1998 14
1999 26
2000 23
2001 19
2002 30
2003 35
2004 32
2005 36
2006 44
2007 48
2008 58
2009 44
2010 65
2011 72
2012 72
2013 84
2014 104
2015 112
2016 111
2017 102
2018 117
2019 114
2020 129
2021 143
2022 152
2023 145
2024 65

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1,977 results

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Page 1
Structural basis of GABA reuptake inhibition.
Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C. Motiwala Z, et al. Nature. 2022 Jun;606(7915):820-826. doi: 10.1038/s41586-022-04814-x. Epub 2022 Jun 8. Nature. 2022. PMID: 35676483 Free PMC article.
Our structure reveals that tiagabine locks GAT1 in the inward-open conformation, by blocking the intracellular gate of the GABA release pathway, and thus suppresses neurotransmitter uptake. Our results provide insights into the mixed-type inhibition of GAT1 by tiaga …
Our structure reveals that tiagabine locks GAT1 in the inward-open conformation, by blocking the intracellular gate of the GABA relea …
Constructing and deconstructing the gate theory of pain.
Mendell LM. Mendell LM. Pain. 2014 Feb;155(2):210-216. doi: 10.1016/j.pain.2013.12.010. Epub 2013 Dec 12. Pain. 2014. PMID: 24334188 Free PMC article. Review.
The gate theory of pain, published by Ronald Melzack and Patrick Wall in Science in 1965, was formulated to provide a mechanism for coding the nociceptive component of cutaneous sensory input. ...It incorporated recently discovered mechanisms of presynaptic control of syna …
The gate theory of pain, published by Ronald Melzack and Patrick Wall in Science in 1965, was formulated to provide a mechanism for c …
Fear balance is maintained by bodily feedback to the insular cortex in mice.
Klein AS, Dolensek N, Weiand C, Gogolla N. Klein AS, et al. Science. 2021 Nov 19;374(6570):1010-1015. doi: 10.1126/science.abj8817. Epub 2021 Nov 18. Science. 2021. PMID: 34793231
Perturbation of body-brain communication by vagus nerve stimulation disrupted the balance between fear extinction and maintenance similar to insular cortex inhibition. Our data reveal that the insular cortex integrates predictive sensory and interoceptive signals to provid …
Perturbation of body-brain communication by vagus nerve stimulation disrupted the balance between fear extinction and maintenance similar to …
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.
Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS. Tolani B, et al. Nat Biotechnol. 2022 Dec;40(12):1834-1844. doi: 10.1038/s41587-022-01386-z. Epub 2022 Jul 25. Nat Biotechnol. 2022. PMID: 35879364 Free PMC article.
Mutations in Ras family proteins are implicated in 33% of human cancers, but direct pharmacological inhibition of Ras mutants remains challenging. As an alternative to direct inhibition, we screened for sensitivities in Ras-mutant cells and discovered 249C as a Ras- …
Mutations in Ras family proteins are implicated in 33% of human cancers, but direct pharmacological inhibition of Ras mutants remains …
A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins.
François A, Low SA, Sypek EI, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Ritola KD, Sharif-Naeini R, Deisseroth K, Delp SL, Malenka RC, Luo L, Hantman AW, Scherrer G. François A, et al. Neuron. 2017 Feb 22;93(4):822-839.e6. doi: 10.1016/j.neuron.2017.01.008. Epub 2017 Feb 2. Neuron. 2017. PMID: 28162807 Free PMC article.
Unexpectedly, we found that RVM GABAergic neurons facilitate mechanical pain by inhibiting dorsal horn enkephalinergic/GABAergic interneurons. We further demonstrate that these interneurons gate sensory inputs and control pain through temporally coordinated enkephal …
Unexpectedly, we found that RVM GABAergic neurons facilitate mechanical pain by inhibiting dorsal horn enkephalinergic/GABAergic inte …
Targeting Trop2 by Bruceine D suppresses breast cancer metastasis by blocking Trop2/β-catenin positive feedback loop.
Tang W, Hu Y, Tu K, Gong Z, Zhu M, Yang T, Sarwar A, Dai B, Zhang D, Zhan Y, Zhang Y. Tang W, et al. J Adv Res. 2024 Apr;58:193-210. doi: 10.1016/j.jare.2023.05.012. Epub 2023 Jun 2. J Adv Res. 2024. PMID: 37271476 Free PMC article.
INTRODUCTION: Tumor-associated calcium signal transducer 2 (Trop2) has been used as a transport gate for cytotoxic agents into cells in antibody-drug conjugate designs because of its expression in a wide range of solid tumors. ...Destabilized beta-catenin caused by BD redu …
INTRODUCTION: Tumor-associated calcium signal transducer 2 (Trop2) has been used as a transport gate for cytotoxic agents into cells …
Pain modulation in the spinal cord.
Woolf CJ. Woolf CJ. Front Pain Res (Lausanne). 2022 Sep 13;3:984042. doi: 10.3389/fpain.2022.984042. eCollection 2022. Front Pain Res (Lausanne). 2022. PMID: 36176710 Free PMC article. Review.
Focus on such active spinal modulation was arguably first introduced by Melzack and Wall in their Spinal Cord Gate Control theory. This theory has had a profound influence on our understanding of pain, and especially its processing, as well as leading directly to the devel …
Focus on such active spinal modulation was arguably first introduced by Melzack and Wall in their Spinal Cord Gate Control theory. Th …
Neuroanatomy, Basal Ganglia.
Young CB, Reddy V, Sonne J. Young CB, et al. 2023 Jul 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jul 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30725826 Free Books & Documents.
It has a multitude of functions associated with reward and cognition but is primarily involved in motor control. In particular, the basal ganglia is considered to be a gate-keeping mechanism for the initiation of motor movement, effectively choosing which actions to allow …
It has a multitude of functions associated with reward and cognition but is primarily involved in motor control. In particular, the basal ga …
Signal peptide mimicry primes Sec61 for client-selective inhibition.
Rehan S, Tranter D, Sharp PP, Craven GB, Lowe E, Anderl JL, Muchamuel T, Abrishami V, Kuivanen S, Wenzell NA, Jennings A, Kalyanaraman C, Strandin T, Javanainen M, Vapalahti O, Jacobson MP, McMinn D, Kirk CJ, Huiskonen JT, Taunton J, Paavilainen VO. Rehan S, et al. Nat Chem Biol. 2023 Sep;19(9):1054-1062. doi: 10.1038/s41589-023-01326-1. Epub 2023 May 11. Nat Chem Biol. 2023. PMID: 37169961 Free PMC article.
Here we describe KZR-8445, a cyclic depsipeptide that targets the Sec61 translocon and selectively disrupts secretory and membrane protein biogenesis in a signal peptide-dependent manner. KZR-8445 potently inhibits the secretion of pro-inflammatory cytokines in primary imm …
Here we describe KZR-8445, a cyclic depsipeptide that targets the Sec61 translocon and selectively disrupts secretory and membrane protein b …
Autophagy gene-dependent intracellular immunity triggered by interferon-γ.
McAllaster MR, Bhushan J, Balce DR, Orvedahl A, Park A, Hwang S, Sullender ME, Sibley LD, Virgin HW. McAllaster MR, et al. mBio. 2023 Oct 31;14(6):e0233223. doi: 10.1128/mbio.02332-23. Online ahead of print. mBio. 2023. PMID: 37905813 Free PMC article.
Enzymes in the UFMylation pathway negatively regulated IFNgamma-induced inhibition of norovirus replication via effects of Ern1. IFNgamma-induced inhibition of norovirus replication required Gate-16 (also termed GabarapL2), Wipi2b, Atg9a, Cul3, and Klhl9 but …
Enzymes in the UFMylation pathway negatively regulated IFNgamma-induced inhibition of norovirus replication via effects of Ern1. IFNg …
1,977 results